William Madison Harper IV, M.D.



1021 Talbotton Road
Columbus, GA 31904
 
PERSONAL
 
Name
William Madison Harper IV, M.D.

Born
March 26, 1953

Marital Status
Married: Elinor Harper
Four Children: Madison, Marc, Carson and Martin

EDUCATION

Undergraduate Information  
High School Plains High School, Plains, GA 1970
College and Degree:

Georgia Southwestern, Americus, GA
B.S. in Biology & Chemistry 1974

   
Graduate Education  
College and Degree:

Medical College of Georgia Augusta, GA M.D. 1978

Honors
Member:
Beta Club National Honor Society, Plains High School
Phi Kappa National Honor Society, GA. Southwestern University
Alpha Omega Alpha National Academic Medical Honor Society, Medical College of GA.
   
Post Graduate Education  
Internship in Surgery:

Medical College of Georgia, Augusta, GA 1978-1979

Resident in Surgery: Medical College of Georgia, Augusta, GA 1979-1980
Resident in Urology :

Medical College of Georgia, Augusta, GA 1980-1982

Chief Resident of Urology:

Medical College of Georgia, Augusta, GA 1982-1983

Professional Education  
 
American Board of Urology, Board Certified 1985, Recertified 1994
Certified Clinical Trial Investigator 2005, by Association of Clinical Research Professionals
Certified Clinical Densitometrist (CCD) 9/22/2005, by The International Society for Clinical Densitometry
   
Licensure  
Georgia Licens # 020726  
Alabama License# 00010803  
   
PRIVATE PRACTICE PROFESSIONAL & OTHER AFFILIATIONS
Urology Center of Columbus, LLC
1021 Talbotton Road
Columbus, GA 31904
(706) 324-7700
(706) 324-7080 fax
Southeastern Medical Research Institute
CEO and Medical Director
2100 North Avenue
Columbus, GA 31904
(706) 653-9637 (706) 324-7080 Fax
 
Hospital Affiliations
Doctor’s Hospital:
Medical Center Hospital:
St. Francis Hospital:
Phenix Regional Hospital:
Hughston Sports Medicine Hospital:
Ambulatory Surgery Center
Columbus, GA.
Columbus, GA
Columbus, GA
Phenix City, AL
Columbus, GA
Columbus, GA
Active
Active
Active
Courtesy
Courtesy
Active
1983-present
1983-present
1983-present
1983-2001 (Hospital closed)
1983-present
2000-present
 
Clinical Faculty
Medical Center 1983
 
Member
Muscogee County Medical Society
Muscogee County Physicians Foundation
Medical Association of Georgia
Chattahoochee Valley Urological Society
Southeastern American Urological Association
American Medical Association
American Urological Association
Impotence Institute of America
American Fertility Society
Society for the Study of Impotence
International Society for the Study of Impotence
International Society for Impotence Research
American Academy of Male Sexual Health
Rotary Club
Big Eddy Club
Association of Clinical Research Professionals ID#158629
American College of Surgeons ID#03087559
 
PROFESSIONAL & OTHER AFFILIATIONS (cont’d)

Positions    
Medical Executive Committee
Chief of Staff
Chief of Surgery
Board of Trustees
Chief of Urology
Medical Executive Committee
Board of Directors
Board of Directors
Board of Directors
Board of Directors
Chairman
Chairman
Board of Directors
Doctor’s Hospital
Doctor’s Hospital
Doctor’s Hospital
Doctor’s Hospital
St. Francis Hospital
St. Francis Hospital
U.S. Diagnostic Labs, Inc.
South GA. Lithotripsy Associates
Quality Healthcare Partnership
American Cancer Society
Columbus Physicians Association
Physician’s Group Inc.
Columbus Health Education& Research Foundation
1990-1996
1992-1994
1992-1994
1993-Present
1991-1993
1991-1993
1994-1996
1992-1999
1999-2001
Present
1998- 2000
1996- 1998
1999- 2000
     
Member Association of Clinical Research Professionals Present
     
Board of Directors
Chairman
Institute for Healthcare Leadership 1st Annual Men’s Health & Fitness
Conference & Expo
2001- 2002
2000
Past President
Past President
Past President
First Chairman
Executive Committee Member
Board of Directors
Advisory Board Member
Chattahoochee Valley Urological Society
Muscogee Co. Medical Society
Muscogee Co. Physicians Foundation
GA Commission on Men’s Health
Muscogee Co. Physicians Foundation
Columbus Research Foundation, Inc.
Men’s Health Network
2000-2001
2002
2001
2001- Present
2002
2002-Present
2004-Present
     
AWARDS    
Physician Of the Year Muscogee County Medical Society 2000

FUNDED RESEARCH

Overactive Bladder/Stress Urinary Incontinence

Protocol 583E-URO-0084-023 – Principle Investigator
A Patient Acceptability Study of a Once-Daily Formulation of ******. A Phase IIIB, Open-Label, Single-Arm Trial in Adult Patients with overactive Bladder and symptoms of Urinary frequency, Urgency, and/or Urge Incontinence.

Protocol: F1J-US-SBCD Principle Investigator
Study of ************ in Women of Different Demographic Characteristics and Co-morbidities with Stress Urinary Incontinence: Evaluation of Efficacy and Safety.

Protocol: A6121120 Pfizer Pharmaceuticals 2005
A randomized, double-blind, placebo controlled, four arm (*****, *****, *****, and ***** plus *****) study to evaluate the clinical efficacy and safety of ***** in men who have frequency and urgency, with or without urinary urge incontinence, with or without bladder outlet obstruction.

Interstitial Cystitis

Protocol MN-001-CL-002 Principle Investigator
A Phase II Randomized, Double-Blind, Placebo-Controlled, Multicenter study to Evaluate the Efficacy and Safety of Two Dosing Regimens of ***** in Patients with Interstitial Cystitis.

Vulvar and Vaginal Atrophy

Protocol: 15-50310 Principle Investigator
Efficacy and Safety of ****** in the Treatment of Vulvar and Vaginal Atrophy (VVA) in Post Menopausal Women: A 12 Week Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Comparing ****** and ******* Daily Doses with Placebo.

Protocol: 15-50310x Principle Investigator
Long-Term Safety of ******* and ****** Oral Daily Doses of ****** in the Treatment of Vulvar and Vaginal Atrophy (VVA) in Postmenopausal Women with an Intact Uterus: A 40-Week Randomized, Double-Blind, Placebo-Controlled, Follow-Up to Protocol 15-15310.

Protocol: 15-50312 Principle Investigator
Long-Term Safety of ******* Oral Daily for the Treatment of Vulvar and Vaginal Atrophy (VVA) in Postmenopausal Women without an Uterus: A 52-Week Open-Label Follow-Up to Protocol 15-15310.

Prostate Cancer

Protocol M97-786 – Principle Investigator
Randomized Prospective Study of Adjuvant Androgen Ablation in Radical Prostatectomy Patients at High-Risk for Disease Reoccurrence.

Protocol 7054US/0007– Principle Investigator

Randomized Double- Blind Comparative Trial of *********** (*******) 150mg vs Placebo Each in Combination With Castration as Second-Line Therapy for Patients With Asymptomatic Metastatic Prostate Cancer.

Principle Investigator
Investigation to Determine the Efficacy of Circulating Total Prostate Specific Antigen (PSA) as an Aid in the Early Detection of Prostate Cancer. Diagnostic Oncology CRO Inc., 1999

Principle Investigator
Investigation to Determine the Efficacy of Circulating Free Prostate Specific Antigen (F-PSA) and the Ration of Concentrations of Circulating F-PSA to PSA as an Aid in the Early Detection of Prostate Cancer. Diagnostic oncology CRO, Inc. 1999

Protocol: MPR-7869-001 Principle Investigator
Phase IIb, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Safety and Efficacy of ***** in Delaying the Systemic Progression of Prostate Cancer in Patients with Intermediate to High Risk of Recurrence with Rising PSA Levels After Prostatectomy and Radiotherapy or Radiotherapy Alone for Localized Disease.
Myriad Pharmaceuticals 2002.

Protocol: TBC-PRO-002 Principle Investigator
A Phase II Randomized, Double Blind, Controlled Study to Evaluate the Safety and Efficacy of ******/******* in Combination with GM-CSF in Patients with Androgen-Independent Adenocarcinoma of the Prostate.

Protocol: L8891 Principle Investigator
Prospective, Observational Registry of the Management of Men with Prostate Cancer and a Rising PSA Following Definitive Surgical or Radiological Treatment of the Primary Tumor: PCA Registry COMPARE

Protocol: G300203 GTX Inc. 2005
A randomized, Double-Blind, Placebo-Controlled, Multicenter Efficacy and Safety of ***** ** for the Prevention of Bone Fractures in Men with Prostate Cancer on Androgen Deprivation Therapy.

Protocol: 20050103 Principle Investigator
A Randomized, Double-Blind, Multicenter study of ******** Compared with Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Men with Hormone-Refractory Prostate Cancer.

Protocol: 20050147
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase III Study of ******* on Prolonging Bone Metastasis-Free Survival in Men with Hormone-Refractory Prostate Cancer.

Bladder Cancer
Protocol CO 98803/DFMO-341– Principle Investigator
Phase III Randomized, Double-Blind Study of ***** vs Placebo in Low Grade Superficial Bladder Cancer.

Erectile Dysfunction

Protocol M01-293– Principle Investigator
A Phase III, Double-Blind, Randomized, Parallel Study Evaluating the Efficacy and safety of ******* (********* tablets) Sublingual (2 and 3mg) in the Treatment of Male Erectile Dysfunction.

Protocol M99-031– Principle Investigator
Phase III at Home Use Study Evaluating Efficacy and safety of Escalating Doses of ******* 2,3 and 4mg in the Treatment of Patients With Erectile Dysfunction.

Protocol M99-038– Principle Investigator
Phase III, 6 Month, Long-Term, Open Label Flexible Dose, Safety Extension Study of ****** Tablets (2,3 and 4mg) in the Treatment of Male Erectile Dysfunction.

Protocol: H6D-MC-LVFN(b) Principle Investigator
An Open-Label Study to Evaluate the Efficacy and Safety of Tadalafil Administered 'On Demand" to Men of Various Populations with Erectile Dysfunction.

Protocol: M01-296. TAP Pharmaceuticals. 2002
A Phase III, 12-month, open-label, felixble dose, safety extension study of ******** tablets (2 and 3mg) in the treatment of male erectile dysfunction.

Benign Prostatic Hyperplasia (BPH)/Prostatitis

Protocol EFC-4428– Principle Investigator
A Double-Blind Randomized Parallel Group Study of ********** 10mg OD Versus Placebo in the Management of Acute Urinary Retention in Patients With a First Episode Due to BPH.

Protocol CAPSS-101– Principle Investigator
A Multi-Center, Double-Blind Study to Compare the Safety and Efficacy of *********** to that of *********** in the Treatment of Chronic Prostatitis.

Principle Investigator
Evaluation of Biomarkers for the Diagnosis and Management of Prostatic Diseases.
BioClinical Partners, Inc., Franklin, MA 1999

Principle Investigator
Multicenter, Double-Blind Study to Compare the Safety and Efficacy of ************ to that of ********** in the Treatment of Chronic and recurrent Prostatitis. Ortho-McNeil Pharmaceuticals 1999

Protocol: L8890 Principle Investigator
'Prospective Observational Registry and Patient Survey of the Management of Men with Symptomatic Benign Prostatic Hyperplasia (BPH): BPH Registry and Patient Survey"

Adult Growth Hormone DeficiencyProtocol CAW G/G 1991– Principle Investigator
Effects of Growth hormone (GH) or Growth Hormone Releasing Hormone (GRF) on Age-Related Insulin resistance, pulmonary Function and Quality of Life.

Protocol: 85-036EXT. Genetech Pharmaceuticals.
National Cooperative Somatropin Surveillance (NCSS) of Nutropin AQ and Nutropin Replacement Therapy in adults with Growth Hormone Deficiency.

Protocol: L3339n Principle Investigator
Genentech National Cooperative Metabolic Study (NCMS) of Nutropin AQ [somatropin (rDNA origin) injection] and Nutropin [somatropin (rDNA origin) for injection] Replacement Therapy in Adults with Growth Hormone Deficiency.

Urinary Tract Infections

Protocol (100286) Bay 56-5864– Principle Investigator

Prospective Randomized, Double-Blind Study Comparing ************ 300mg PO BID for Five Days With ********/*********** 160/800mg PO BID for Five Days in the Treatment of Patients With Acute, Uncomplicated Lower Urinary Tract Infections.

Protocol: CAPSS-292 Principle Investigator
A Double-Blind, Randomized, Parallel Group Trial of Ditropan XL (oxybutynin chloride) Extended Release Tablets or Placebo in Combination with FLOMAX (tamsulosin hydrochloride) For The Treatment of Lower Urinary Tract Symptoms.

Protocol: CAPSS-349 Ortho-McNeil Pharmaceuticals 2005
A Study to Compare the Safety and Efficacy of Once Daily ****** versus Twice Daily ***** in the Treatment of Complicated Urinary Tract Infection and Acute Uncomplicated Pyelonephritis.

Investigator Initiated TrialsProtocol MF SHIMMED– Principle Investigator
Sponsor: William M. Harper IV, MD
Minority Focused Sexual Health Inventory for Men as Model for evaluation and Detection of Men’s Health Issues.

Protocol: X3397n
The Incidence of Adult Growth Hormone Deficiency Secondary to Pituitary Adenomas and Head trauma in Hypogonadal Males Presenting in the Urological Practice.

Lectureships
May 10, 2000 Sunshine Biscuits. Columbus, Georgia 'Men’s Health"
   
May 23, 2000 Kiwanis Club of Columbus. Columbus, Georgia 'Men’s Health"
   
June 16, 2000 First Annual Men’s Health and Fitness Conference and Expo. Columbus, Georgia'Male exuality"
   
January 20, 2001 Diabetes University. Columbus Trade Center American Diabetes Association. Columbus, Georgia. 'Erectile Dysfunction and Diabetes"
   
March 8, 2001 Alza Pharmaceuticals. Columbus, Georgia 'Urinary Incontinence"
   
April 3, 2001 OPALS Health Seminar. Columbus, Georgia 'A Nation’s Healthcare Crisis and Georgia’s Solution HB 1235"
   
April 24, 2001 Grand Rounds. The Medical Center. Columbus, Georgia 'A Nation’s Healthcare Crisis and Georgia’s Solution HB 1235"
   
August 6, 2001 PHRMa Task Force. Atlanta, Georgia 'A Nation’s Healthcare Crisis and Georgia’s Solution HB 1235"
   
August 7, 2001 Tri County Medical Society. Warm Springs, Georgia 'A Nation’s Healthcare Crisis and Georgia’s Solution HB 1235"
   
September 25, 2001 Grand Rounds. The Medical Center. Columbus, Georgia 'One to One" Erectile Dysfunction.
   
September 25, 2001 Health Matters. St. Francis Hospital Columbus, Georgia. 'Prostate Diseases"
   
October 25, 2001 Physicians Leadership Forum. Columbus, Georgia 'A Nation’s Healthcare Crisis and Georgia’s Solution HB 1235"
   
October 27, 2001 Health in Action. Buick Challenge at Calloway Gardens. 'A Nation’s Healthcare Crisis and Georgia’s Solution HB 1235"
   
January 12, 2002 Diabetes University. Columbus Trade Center American Diabetes Association. Columbus, Georgia. 'Erectile Dysfunction and Diabetes"
   
January 24, 2002 Fort Benning Medical Society. Columbus, GA 'One to One"
   
January 28, 2002 Pfizer Pharmaceuticals. Little Rock, AR 'One to One"
   
January 29, 2002 Pfizer Pharmaceuticals. Little Rock, AR 'One to One"
   
January 29, 2002 Pfizer Pharmaceuticals. Memphis, TN 'One to One"
   
February 5, 2002 Grand Rounds. The Medical Center. Columbus, Georgia 'One to One"
   
February 7, 2002 Ortho McNeil Pharmaceuticals. Columbus, Georgia 'Stress Urinary Incontinence"
   
February 28, 2002 Diabetes Support Group. The Medical Center. Columbus, GA. 'Erectile Dysfunction and Diabetes"
   
March 5-6, 2002 ED Expert Advisory Panel. Pfizer Pharmaceuticals. Atlanta, Georgia. 'One to One"
   
March 7, 2002 Pfizer Pharmaceuticals. Springer Opera House. Columbus, Georgia. 'One to One"
   
March 13, 2002 Grand Rounds. Valley, Alabama 'One to One"
   
April 16, 2002 Georgia Association of Physicians Assistants. Columbus, Georgia. 'One to One"
   
April 19, 2002 Health Matters. St. Francis Hospital. 'Stress Urinary Incontinence"
   
April 29-30, 2002 Pfizer Pharmaceuticals. Birmingham, Alabama 'One to One"
   
May 1, 2002 Rotary of Columbus. Columbus, Georgia 'One to One"
   
July 18, 2002 Pfizer Pharmaceuticals. Columbus, Georgia 'One to One"
   
August 19, 2002 Solvay Pharmaceuticals. Columbus, Georgia 'The Clinical Importance of Identifying and Treating Hypogonadism"
   
September 28, 2002 Nichols Chapel. Phenix City, Alabama ' Prostate Cancer"
   
October 15, 2002 Pfizer Pharmaceuticals. Columbus, Georgia ' One to One"
   
January 13, 2003 Pfizer Pharmaceuticals. Columbus, Georgia Columbus Clinic. 'One to One"
   
January 15, 2003 American Medical Systems. Columbus, Georgia TVT Sling Seminar
   
January 16, 2003 Pfizer Pharmaceuticals. Columbus, Georgia GA Physicians Assistant Organization. 'One to One"
   
March 12, 2003 Pfizer Pharmaceuticals. Columbus, Georgia "PROVEN"
   
March 21, 2003 Pfizer Pharmaceuticals. Columbus, Georgia “ PROVEN”
   
April 1, 2003 Pfizer Pharmaceuticals. Columbus, Georgia “ PROVEN”
   
April 19, 2003 Pfizer Pharmaceuticals. Columbus, Georgia Chattahoochee Valley Urological Society “Erectile Dysfunction”
   
April 29, 2003 American Medical Systems. Columbus, Georgia “Erectile Dysfunction”
   
May 13, 2003 Pfizer Pharmaceuticals. Columbus, Georgia Grand Rounds at the Medical Center “PROVEN”
   
June 1, 2003 Genentech Pharmaceuticals. San Francisco, CA “Adult Growth Hormone Deficiency”
   
June 13, 2003 Genentech Pharmaceuticals “Adult Growth Hormone Deficiency”
   
June 17, 2003 Pfizer Pharmaceuticals. Columbus, Georgia “PROVEN” Columbus Naval Museum
   
September 23, 2003 Pfizer Pharmaceuticals. Columbus, Georgia “Proven” Green Island Country Club
   
October 28, 2003 Pfizer Pharmaceuticals. Columbus, GA “Proven” Miriam’s Cafe
   
November 11, 2003 Pfizer Pharmaceuticals. Warm Springs, GA. Steakhouse.“Treatment of Urological Diseases for Primary Car & ED”
   
February 3, 2004 Pfizer Pharmaceuticals. Columbus, GA. Gre Island Country Club.“Treatment of Urological Diseases for Primary Car & ED”
   
March 10, 2004 Pfizer Pharmaceuticals. Columbus, GA. Medical C “Treatment of Urological Diseases for Primary Car & ED”
   
April 13, 2004 Pfizer Pharmaceuticals. Montgomery, AL “Treatment of Urological Diseases for Primary Car& ED”
   
April 19, 2004 Pfizer Pharmaceuticals. Columbus, GA. Urology C “Overactive Bladder”
   
June 24, 2004 Pfizer Pharmaceuticals. Ft. Benning, Martin Army Hospital “Overactive Bladder”
   
July 14, 2004 Pfizer Pharmaceuticals. Columbus, Beth Martin’s office “Proven”
   
July 27, 2004 Pfizer Pharmaceuticals. Columbus, GA. River Club “Proven”
   
July 28, 2004 Pfizer Pharmaceuticals. Columbus, GA. River Club “Proven”
   
August 3, 2004 Pfizer Pharmaceuticals. Columbus, GA. River Club “Proven”
   
August 25, 2004 Pfizer Pharmaceuticals. Columbus, GA. River Club “Proven”
   
August 26, 2004 Pfizer Pharmaceuticals. Anniston, AL Lunch and dinner round table discussions on ED.
   
September 28, 2004 Pfizer Pharmaceuticals. Columbus, GA. Buckhead “Powerful Performance, When You Want It”
   
October 5, 2004 Pfizer Pharmaceuticals, Buena Vista, GA Lunch round table discussion on ED.
   

October 26, 2004

Pfizer Pharmaceuticals. Columbus, GA. The Medical Center Grand Rounds “Overactive Bladder”